Phagocytic Cell Deficiencies


Phagocytes include white blood cells (neutrophils and macrophages) that engulf and kill antibody coated foreign invaders. Phagocytes can be defective either in their ability to kill pathogens or in their ability to move to the site of an infection. In either case, the defect results in increased infections.

The most severe form of phagocytic cell deficiency is:

Chronic Granulomatous Disease

Chronic Granulamatous Disease (CGD) is an inherited deficiency of molecules needed by neutrophils to kill certain infectious organisms. People with chronic granulomatous disease develop frequent and severe infections of the skin, lungs and bones and develop localised, swollen collections of inflamed tissue called granulomas.

IDFNZ Chronic Granulamatous Disease PAMPHLET

IPOPI Chronic Granulomatous Disease


Others include:


Neutropenia is characterized by an abnormally low number of neutrophils.

Understanding Severe Chronic Neutropenia_SCNIR

Severe Chronic Neutropenia International Registry website (make sure you view in “English”)

Leukocyte Adhesion Defect (LAD)

Chediak Higashi Syndrome (CHS)

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