Complement Deficiencies

The complement system consists of a group of proteins that attach to antibody coated foreign invaders like bacteria and viruses. People with complement deficiencies may develop antibodies that react against the body’s own cells and tissues.

Examples of Complement Deficiencies include:

Complement Component Deficiencies

(e.g. C1, C2, C3, C4, C5, C6, C7 etc)

C1 Esterase Inhibitor Deficiency

Hereditary Angioedema

Hereditary Angioedema (HAE) is due to a deficiency of C1 esterase inhibitor. HAE is a rare genetic disorder characterized by episodes of swelling (edema attacks) in different areas of the skin or the internal organs. In particular, it occurs in the upper respiratory tract and intestine.

For more information on Hereditary Angioedema:

ASCIA (Australasian Society of Clinical Immunologists and Allergists)

HAE Australasia Website

HAEi  International Patient Organisation for C1 Inhibitor Deficiencies website


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