Antibodies are proteins made by specialized white blood cells: B cells (B lymphocytes) and plasma cells. The function of antibodies is to recognise infectious agents so that they can be blocked. Examples of antibody deficiencies are:
Common Variable Immune Deficiency (CVID)
Common Variable Immune Deficiency (CVID) is the most common form of antibody deficiency, usually presenting with recurrent chest and sinus infections in childhood or early adulthood, although most cases are diagnosed in adults. Early recognition can prevent bronchiectasis – permanent damage to the lungs. Read More
- ASCIA Common Variable Immune Deficiency Pamphlet ASCIA publication. PDF format, 674KB.
- IDFNZ CVID Pamphlet IDF New Zealand Pamphlet on Common Variable Immune Deficiency. PDF format, 311 KB.
- IPOPI CVID Booklet IPOPI pamphlet on Common Variable Immune Deficiency. PDF format, 2509 KB.
X-linked Agammaglobulinaemia (Bruton’s)
X-linked Agammaglobulinaemia can present in infancy, later childhood or adulthood. Infants with this deficiency develop recurrent pus producing infections of the ears, lungs, sinuses and bones and can get infections in the bloodstream and internal organs. They are also susceptible to certain viruses such as hepatitis and polio.
- IDFANZ XLA Pamphlet IDF New Zealand Pamphlet on X-Linked Agammaglobulinaemia. PDF format, 106 KB.
- IPOPI X-linked Agammaglobulinemia Booklet IPOPI pamphlet on X-Linked Agammaglobulinaemia. PDF format, 2507 KB.
X-linked or Autosomal Hyper IgM Syndrome
- IPOPI Hyper IgM Syndrome IPOPI pamphlet on Hyper IgM Syndrome. PDF format, 2504 KB.
- IDF US Patient Family Handbook 4 Ed Ch8 Hyper IgM Syndrome IDF excerpt Patient Handbook 4th Edition, Chapter 8 Hyper IgM Syndrome. PDF format, 143 KB.
Selective IgA Deficiency
- IDF NZ Selective IgA Deficiency IDF New Zealand pamphlet on Selective IgA Deficiency. PDF format, 119 KB.
- IDF Patient Handbook Ch4 Selective IgA Deficiency IDF excerpt Patient Handbook 4th Edition, Chapter 4 Selective IgA Deficiency. PDF format 141 KB.
IgG Subclass Deficiency and Specific Antibody Deficiency
- IDF US Information IgG Subclass Deficiency & Specific Antibody Deficiency IDF US Information on Selective IgA Deficiency. PDF format 141 KB.
Hyper IgE Syndrome
- IDF US Information Hyper IgE Syndrome IDF US information on Hyper IgE Syndrome. PDF format, 161 KB.
Whim is a very rare PID. Whim is the acronym for Warts, Hypogammaglobulinemia, Immunodeficieny, Myelokathexis. It is a genetic syndrome with dominant autosomal inheritance characterized by chronic neutropenia associated with bone marrow hypercellularity (myelokathexis).
Resources: These are links to a few sites with Whim Syndrome Information