STAT3

STAT3 is a transcriptional factor involved in a broad spectrum of adaptive and innate immune functions.

STAT3 GOF DISEASE

STAT3 gain-of-function disease is a rare genetic disorder of the immune system. STAT3 is a signal transducer
and activator of transcription 3, The effect caused by this mutation is that the gene’s protein becomes overactive.
STAT3 GOF disease is an early-onset autoimmune and lymphoproliferative disease. The symptoms vary and can include swelling of the lymph nodes (lymphadenopathy), reductions in the number of blood cells (autoimmune cytopenias), autoimmunity that affects multiple organs and tissues, infections, eczema, and in some cases, short stature.

STAT3 GAIN OF FUNCTION FACT SHEET_NIAID_NIH

STAT3 ARTICLES

STAT3 TOO MUCH MAY BE WORSE THAN NOT ENOUGH_2015_BLOOD_MILLER HAAPANIEMI_ASH

STAT 3 A YEAR IN REVIEW 2017 _NIH_FORBES MILNER HADDAD

THE YIN & YANG IF STAT 3 IN DISEASE_2015_JCI_ VOGEL MILNER COOPER

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